Cytoplasmic gelsolin increases mitochondrial activity and reduces Aβ burden in a mouse model of Alzheimer's disease

@article{Antequera2009CytoplasmicGI,
  title={Cytoplasmic gelsolin increases mitochondrial activity and reduces Aβ burden in a mouse model of Alzheimer's disease},
  author={Desire{\'e} Antequera and Teo Vargas and Cristina Ugalde and Carlos Spuch and Eva Carro},
  journal={Neurobiology of Disease},
  year={2009},
  volume={36},
  pages={42-50}
}
Accumulation of amyloid-beta (Abeta) peptides is thought to be a critical event in the pathology of Alzheimer's disease (AD), because they induce multiple neurotoxic effects, including mitochondrial dysfunction and apoptotic cell death. Therefore the reduction of Abeta is considered a primary therapeutic target. Gelsolin, an Abeta binding protein, has been shown to inhibit apoptosis, although the underlying mechanism is unclear. To clarify these effects, we manipulated cytoplasmic gelsolin… CONTINUE READING

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