Cytoplasmic gatekeepers of K+-channel flux: a structural perspective.

  title={Cytoplasmic gatekeepers of K+-channel flux: a structural perspective.},
  author={Tarmo P. Roosild and Khanh-Tuoc L{\^e} and Senyon Choe},
  journal={Trends in biochemical sciences},
  volume={29 1},
Recently, rapid progress in our structural knowledge of K(+)-selective channels has started to provide a basis for comprehending the biophysical machinery underlying their electrophysiological properties. These studies have begun to reveal how a diverse array of distinct, cytoplasmically positioned domains affect the activity of associated channels. Some of these establish functional diversity by selectively mediating channel assembly. More importantly, these cytoplasmic domains couple… CONTINUE READING

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