Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy

Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers worldwide. CD147 (EMMPRIN or basigin) is a leading gene relating to hepatocarcinogenesis and metastasis, and is detected in transmembrane, exosome or circulating forms in HCC patients. The endosome recycling of CD147 further enhances the function of this oncoprotein from a… (More)
DOI: 10.1038/cddis.2017.251

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Cite this paper

@inproceedings{Wu2017CytoplasmicFO, title={Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagy}, author={Bo Wu and Jian Cui and Xiang-min Yang and Zhenyu Liu and Fei Song and Ling Li and Jian-li Jiang and Zhi Chen}, booktitle={Cell death & disease}, year={2017} }