Cytoplasmic expression of the JM403 antigen GlcA-GlcNH3+ on heparan sulfate glycosaminoglycan in mammary carcinomas—a novel proliferative biomarker for breast cancers with high malignancy

@article{Fujii2010CytoplasmicEO,
  title={Cytoplasmic expression of the JM403 antigen GlcA-GlcNH3+ on heparan sulfate glycosaminoglycan in mammary carcinomas—a novel proliferative biomarker for breast cancers with high malignancy},
  author={Masahiro Fujii and Akiko Yusa and Yukihiro Yokoyama and Toshio Kokuryo and Nobuyuki Tsunoda and Koji Oda and Masato Nagino and Tsuyoshi Ishimaru and Yoshie Shimoyama and Hirotoshi Utsunomiya and Hiroji Iwata and Yoshiko Itoh and Johbu Itoh and Reiji Kannagi and Mamoru Kyogashima},
  journal={Glycoconjugate Journal},
  year={2010},
  volume={27},
  pages={661-672}
}
The expressions of heparan sulfate glycosaminoglycans (HSGAGs) in breast carcinoma specimens from 60 patients were immunohistochemically investigated using monoclonal antibodies (mAbs) that recognized different epitopes of the glycan structure. Cytoplasmic expression of GlcA-GlcNH3+ on HSGAG was detected in carcinomas at high frequency (58.3%) using mAb JM403, whereas it was almost undetectable in normal breast ducts. This cytoplasmic expression was confirmed using confocal laser scanning… CONTINUE READING

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