Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes.

@article{Young2000CytoplasmicDA,
  title={Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes.},
  author={Aideen C.M. Young and Jason B. Dictenberg and Aruna Purohit and Richard Allan Tuft and Stephen John Doxsey},
  journal={Molecular biology of the cell},
  year={2000},
  volume={11 6},
  pages={
          2047-56
        }
}
Centrosome assembly is important for mitotic spindle formation and if defective may contribute to genomic instability in cancer. Here we show that in somatic cells centrosome assembly of two proteins involved in microtubule nucleation, pericentrin and gamma tubulin, is inhibited in the absence of microtubules. A more potent inhibitory effect on centrosome assembly of these proteins is observed after specific disruption of the microtubule motor cytoplasmic dynein by microinjection of dynein… CONTINUE READING

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