Cytoplasmic domain of E-selectin contains a non-tyrosine endocytosis signal.

  title={Cytoplasmic domain of E-selectin contains a non-tyrosine endocytosis signal.},
  author={Peter I Chuang and Bradford A. Young and Ravi R Thiagarajan and Carla A Cornejo and Robert K. Winn and John Harlan},
  journal={The Journal of biological chemistry},
  volume={272 40},
E-selectin is an activation-dependent, endothelial cell-restricted adhesion molecule that is internalized and degraded rapidly once expressed on the cell surface. Tyrosine-containing structural motifs play an important role in the internalization of a number of integral proteins, and the membrane-proximal E-selectin cytoplasmic tyrosine residue (Tyr582) conforms to the endocytosis motif proposed previously. To determine the endocytosis motif in E-selectin, we selectively introduced truncation… CONTINUE READING


Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…