Cytoplasmic chromatin triggers inflammation in senescence and cancer

  title={Cytoplasmic chromatin triggers inflammation in senescence and cancer},
  author={Zhixun Dou and Kanad Ghosh and Maria Grazia Vizioli and Jiajun Zhu and Payel Sen and Kirk J Wangensteen and Johayra Simithy and Yemin Lan and Yanping Lin and Zhuo Long Zhou and Brian C. Capell and Caiyue Xu and Mingang Xu and Julia E. Kieckhaefer and Tianying Jiang and Michal Shoshkes-Carmel and K. M. Ahasan Al Tanim and Glen N Barber and John T Seykora and Sarah E. Millar and Klaus H. Kaestner and Benjamin A Garcia and Peter David Adams and Shelley L Berger},
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory responses. The functional significance of chromatin in the cytoplasm is unclear. Here we show that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS… CONTINUE READING


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