Cytoplasmic beta-catenin accumulation is a good prognostic marker in upper and lower gastrointestinal adenocarcinomas.

@article{Norwood2010CytoplasmicBA,
  title={Cytoplasmic beta-catenin accumulation is a good prognostic marker in upper and lower gastrointestinal adenocarcinomas.},
  author={Michael G. A. Norwood and Neil Bailey and Manoj Nanji and Richard S. Gillies and Anna Nicholson and Sukh Ubhi and Jane J Darnton and Richard S. Steyn and Chris Womack and Andrew K Hughes and David Hemingway and Rebecca B. Harrison and Rachel Waters and Janusz Antoni Z Jankowski},
  journal={Histopathology},
  year={2010},
  volume={57 1},
  pages={101-11}
}
AIMS beta-Catenin is an important molecule in cancer biology. Membranous beta-catenin enhances cellular differentiation and inhibits invasion by its action on E-cadherin. The aim was to ascertain whether the cellular expression of these molecules in colorectal and oesophageal cancer specimens is associated with survival in patients with gastrointestinal cancer. METHODS AND RESULTS Tumour samples from 149 patients undergoing resection for colorectal adenocarcinoma and 147 patients undergoing… CONTINUE READING