Cytoplasmic and nuclear quality control and turnover of single-stranded RNA modulate post-transcriptional gene silencing in plants

@inproceedings{Moreno2013CytoplasmicAN,
  title={Cytoplasmic and nuclear quality control and turnover of single-stranded RNA modulate post-transcriptional gene silencing in plants},
  author={Ana Beatriz Moreno and Angel Emilio Mart{\'i}nez de Alba and Florian Bardou and Mart{\'i}n Crespi and Herv{\'e} Vaucheret and Alexis Maizel and Allison C. Mallory},
  booktitle={Nucleic acids research},
  year={2013}
}
Eukaryotic RNA quality control (RQC) uses both endonucleolytic and exonucleolytic degradation to eliminate dysfunctional RNAs. In addition, endogenous and exogenous RNAs are degraded through post-transcriptional gene silencing (PTGS), which is triggered by the production of double-stranded (ds)RNAs and proceeds through short-interfering (si)RNA-directed ARGONAUTE-mediated endonucleolytic cleavage. Compromising cytoplasmic or nuclear 5'-3' exoribonuclease function enhances sense-transgene (S… CONTINUE READING
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