Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases.

@article{Zhu2002CytoplasmicAO,
  title={Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases.},
  author={Jian-hui Zhu and Scott M. Kulich and Tim D Oury and Charleen T Chu},
  journal={The American journal of pathology},
  year={2002},
  volume={161 6},
  pages={2087-98}
}
A better understanding of cellular mechanisms that occur in Parkinson's disease and related Lewy body diseases is essential for development of new therapies. We previously found that 6-hydroxydopamine (6-OHDA) elicits sustained extracellular signal-regulated kinase (ERK) activation that contributes to neuronal cell death in vitro. As subcellular localization of activated kinases affect accessibility to downstream targets, we examined spatial patterns of ERK phosphorylation in 6-OHDA-treated… CONTINUE READING
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