Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells.

@article{Hostetter2008CytoplasmicAO,
  title={Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells.},
  author={Christine L. Hostetter and Lauren A. Licata and Agnieszka K. Witkiewicz and Christina L. Costantino and Charles J Yeo and Jonathan R. Brody and Judith Clancy Keen},
  journal={Cancer biology & therapy},
  year={2008},
  volume={7 9},
  pages={1496-506}
}
With prolonged exposure, a majority of estrogen receptor positive cancers develop resistance to tamoxifen and subsequent therapies including selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs). While much is known about overexpression of key growth promoting receptors including EGF, erbB2/Her2 and IGF receptors and subsequent activation of MAPK signaling associated with resistance, the underlying mechanism in the development of resistance still remains unknown. We… CONTINUE READING

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