Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein.

@article{Chen2014CytoplasmicHR,
  title={Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein.},
  author={Jianbo Chen and David Grunwald and Luca Sardo and Andrea Galli and Sergey Plisov and Olga A. Nikolaitchik and De Qing Chen and Stephen J. Lockett and Daniel R Larson and Vinay K Pathak and Wei-Shau Hu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 48},
  pages={E5205-13}
}
Full-length HIV-1 RNA plays a central role in viral replication by serving as the mRNA for essential viral proteins and as the genome packaged into infectious virions. Proper RNA trafficking is required for the functions of RNA and its encoded proteins; however, the mechanism by which HIV-1 RNA is transported within the cytoplasm remains undefined. Full-length HIV-1 RNA transport is further complicated when group-specific antigen (Gag) protein is expressed, because a significant portion of HIV… CONTINUE READING
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