Cytoplasmic Fungal Lipases Release Fungicides from Ultra-Deformable Vesicular Drug Carriers

@inproceedings{Steinberg2012CytoplasmicFL,
  title={Cytoplasmic Fungal Lipases Release Fungicides from Ultra-Deformable Vesicular Drug Carriers},
  author={Gero Steinberg},
  booktitle={PloS one},
  year={2012}
}
The Transfersome® is a lipid vesicle that contains membrane softeners, such as Tween 80, to make it ultra-deformable. This feature makes the Transfersome® an efficient carrier for delivery of therapeutic drugs across the skin barrier. It was reported that TDT 067 (a topical formulation of 15 mg/ml terbinafine in Transfersome® vesicles) has a much more potent antifungal activity in vitro compared with conventional terbinafine, which is a water-insoluble fungicide. Here we use ultra-structural… CONTINUE READING

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The dynamic fungal cell

G Steinberg, M Schuster
Fungal Biol Rev • 2011
View 7 Excerpts
Highly Influenced

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