Cytoplasmic Dynein and Dynactin Are Required for the Transport of Microtubules into the Axon

@article{Ahmad1998CytoplasmicDA,
  title={Cytoplasmic Dynein and Dynactin Are Required for the Transport of Microtubules into the Axon },
  author={Fridoon J. Ahmad and Christophe de Jesus Echeverri and Richard B Vallee and Peter W. Baas},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={140},
  pages={391 - 401}
}
Previous work from our laboratory suggested that microtubules are released from the neuronal centrosome and then transported into the axon (Ahmad, F.J., and P.W. Baas. 1995. J. Cell Sci. 108: 2761-2769). In these studies, cultured sympathetic neurons were treated with nocodazole to depolymerize most of their microtubule polymer, rinsed free of the drug for a few minutes to permit a burst of microtubule assembly from the centrosome, and then exposed to nanomolar levels of vinblastine to suppress… CONTINUE READING

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