Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response

@article{Yang2019CytoplasmicDD,
  title={Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response},
  author={Y. Yang and Thea L Willis and R. Button and Conor J. Strang and Yuhua Fu and Xue Wen and P. R. C. Grayson and Tracey Evans and Rebecca J. Sipthorpe and S. Roberts and B. Hu and Jianke Zhang and B. Lu and S. Luo},
  journal={Nature Communications},
  year={2019},
  volume={10}
}
Autophagy cargo recognition and clearance are essential for intracellular protein quality control. SQSTM1/p62 sequesters intracellular aberrant proteins and mediates cargo delivery for their selective autophagic degradation. The formation of p62 non-membrane-bound liquid compartments is critical for its function as a cargo receptor. The regulation of p62 phase separation/condensation has yet been poorly characterised. Using an unbiased yeast two-hybrid screening and complementary approaches, we… Expand
MOAP‐1‐mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling
Ubiquitin‐Modulated Phase Separation of Shuttle Proteins: Does Condensate Formation Promote Protein Degradation?
  • T. P. Dao, C. Castañeda
  • Chemistry, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2020
p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles
Mechanisms governing autophagosome biogenesis
  • H. Nakatogawa
  • Chemistry, Medicine
  • Nature Reviews Molecular Cell Biology
  • 2020
Protein quality control by the proteasome and autophagy: A regulatory role of ubiquitin and liquid-liquid phase separation.
Beyond repression of Nrf2: An update on Keap1.
...
1
2
3
...

References

SHOWING 1-10 OF 76 REFERENCES
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
...
1
2
3
4
5
...