Cytoplasmic Ape1 Expression Elevated by p53 Aberration May Predict Survival and Relapse in Resected Non-Small Cell Lung Cancer

@article{Wu2012CytoplasmicAE,
  title={Cytoplasmic Ape1 Expression Elevated by p53 Aberration May Predict Survival and Relapse in Resected Non-Small Cell Lung Cancer},
  author={Heng-Hsiung Wu and Ya-Chiung Chu and Lee Wang Wang and MS Lung-HungTsai and Ming-Ching Lee and Chi-Yi Chen and Shwn-Huey Shieh and Ya-Wen Cheng and Huei Lee},
  journal={Annals of Surgical Oncology},
  year={2012},
  volume={20},
  pages={336-347}
}
Subcellular localization of apurinic/apyrimidinic endonuclease-1/redox factor-1 (Ape1) has been demonstrated to promote lung tumor malignancy via NF-κB activation. We hypothesized that increased cytoplasmic Ape1 expression might cause NF-κB activation by p53 aberration, and result in poor outcome in non-small cell lung cancer (NSCLC). Herein, knockdown of E6 or p53 and overexpression of E6 were performed in various lung cancer cells to test whether cytoplasmic Ape1 expression could be elevated… CONTINUE READING
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