Cytoplasmic, nuclear, and total PBK/TOPK expression is associated with prognosis in colorectal cancer patients: A retrospective analysis based on immunohistochemistry stain of tissue microarrays

@article{Su2018CytoplasmicNA,
  title={Cytoplasmic, nuclear, and total PBK/TOPK expression is associated with prognosis in colorectal cancer patients: A retrospective analysis based on immunohistochemistry stain of tissue microarrays},
  author={Tzu-Cheng Su and Chun-Yu Chen and Wen-Che Tsai and Hui-Ting Hsu and Hsu-Heng Yen and Wen-Wei Sung and Chih-Jung Chen},
  journal={PLoS ONE},
  year={2018},
  volume={13}
}
  • Tzu-Cheng Su, Chun-Yu Chen, +4 authors Chih-Jung Chen
  • Published 2018
  • Medicine
  • PLoS ONE
  • Objective PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) regulates components of the cell cycle, including cell growth, immune responses, DNA damage repair, apoptosis, and inflammation. PBK/TOPK may also accelerate tumorigenesis in colorectal cancer. Methods We investigated the impact of PBK/TOPK on the clinical outcome of colorectal cancer patients to further identify its role in colorectal cancer. PBK/TOPK immunoreactivity was analyzed by immunohistochemistry in 162 cancer… CONTINUE READING
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