Cytoplasm-localized SIRT1 enhances apoptosis.

  title={Cytoplasm-localized SIRT1 enhances apoptosis.},
  author={Qihuang Jin and Tingting Yan and Xinjian Ge and Cheng Sun and Xianglin Shi and Qiwei Zhai},
  journal={Journal of cellular physiology},
  volume={213 1},
In general, SIRT1 is localized in nuclei. Here, we showed that endogenous and exogenous SIRT1 were both able to partially localize in cytoplasm in certain cell lines, and cytoplasm-localized SIRT1 was associated with apoptosis and led to increased sensitivity to apoptosis. Furthermore, we demonstrated that translocation of nucleus-localized SIRT1 from nuclei to cytoplasm was the main pathway leading to localization of SIRT1 in cytoplasm. In HeLa cells, wild type SIRT1 was completely localized… CONTINUE READING


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