Cytopathologic and neurochemical correlates of progression to motor/cognitive impairment in SIV-infected rhesus monkeys.

@article{Rausch1994CytopathologicAN,
  title={Cytopathologic and neurochemical correlates of progression to motor/cognitive impairment in SIV-infected rhesus monkeys.},
  author={Dianne M. Rausch and Melvyn P. Heyes and Elisabeth A Murray and J Lendvay and Leroy R. Sharer and Jerrold M Ward and Susan J. Rehm and Donatus Nohr and Eberhard Weihe and Lee E. Eiden},
  journal={Journal of neuropathology and experimental neurology},
  year={1994},
  volume={53 2},
  pages={165-75}
}
Neurochemical, pathologic, virologic, and histochemical correlates of simian immunodeficiency virus (SIV)-associated central nervous system (CNS) dysfunction were assessed serially or at necropsy in rhesus monkeys that exhibited motor and cognitive deficits after SIV infection. Some infected monkeys presented with signs of acquired immunodeficiency disease (AIDS) at the time of sacrifice. Seven of eight animals exhibited motor skill impairment which was associated with elevated quinolinic acid… CONTINUE READING
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