Cytopathic hypoxia in sepsis.

  title={Cytopathic hypoxia in sepsis.},
  author={Mitchell P. Fink},
  journal={Acta anaesthesiologica Scandinavica. Supplementum},
  • Mitchell P. Fink
  • Published 1997 in Acta anaesthesiologica Scandinavica. Supplementum
Diminished availability of oxygen at the cellular level might account for organ dysfunction in sepsis. Although the classical forms of tissue hypoxia due to hypoxemia, anemia, or inadequate perfusion all might be important under some conditions, it seems increasingly likely that a fourth mechanism, namely cytopathic hypoxia, might play a role as well. The term cytopathic hypoxia is used to denote diminished production of adenosine triphosphate (ATP) despite normal (or even supranormal) PO2… CONTINUE READING
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