Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents.

@article{Tanaka2007CytometryOA,
  title={Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents.},
  author={Toshiki P. Tanaka and Xuan Huang and H. Dorota Halicka and Haishuang Zhao and Frank Traganos and Anthony P. Albino and Wei Dai and Zbigniew Darzynkiewicz},
  journal={Cytometry. Part A : the journal of the International Society for Analytical Cytology},
  year={2007},
  volume={71 9},
  pages={648-61}
}
This review covers the topic of cytometric assessment of activation of Ataxia telangiectasia mutated (ATM) protein kinase and histone H2AX phosphorylation on Ser139 in response to DNA damage, particularly the damage that involves formation of DNA double-strand breaks. Briefly described are molecular mechanisms associated with activation of ATM and the downstream events that lead to recruitment of DNA repair machinery, engagement of cell cycle checkpoints, and activation of apoptotic pathway… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 82 extracted citations

Similar Papers

Loading similar papers…