Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells.

@article{Sedmak1994CytomegalovirusIM,
  title={Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells.},
  author={Daniel D. Sedmak and Anna Guglielmo and Deborah A Knight and Dan J Birmingham and Emina Huang and W. James Waldman},
  journal={The American journal of pathology},
  year={1994},
  volume={144 4},
  pages={683-92}
}
Persistent human cytomegalovirus (HCMV) infections are responsible for significant morbidity and mortality in immunocompromised individuals. One mechanism by which HCMV may develop persistence after primary infection is through inhibition of host cell human leukocyte antigen (HLA) class II expression with resultant escape from normal antiviral immune surveillance. Immunofluorescence flow cytometry of human endothelial cell (EC) cultures infected with HCMV AD169 and an EC propagated strain, VHL… CONTINUE READING

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