Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.

Abstract

Antigens of pathogenic microbes that mimic autoantigens are thought to be responsible for the activation of autoreactive T cells. Viral infections have been associated with the development of the neuroendocrine autoimmune diseases type 1 diabetes and stiff-man syndrome, but the mechanism is unknown. These diseases share glutamic acid decarboxylase (GAD65… (More)

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@article{Hiemstra2001CytomegalovirusIA, title={Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.}, author={Henk Hiemstra and Nanette C. Schloot and Peter A. van Veelen and S J Willemen and Kees L. C. M. Franken and Jon J. van Rood and Rehana de Vries and A. Chaudhuri and Pamela Behan and Jan Wouter Drijfhout and B. O. Roep}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2001}, volume={98 7}, pages={3988-91} }