Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression.

  title={Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression.},
  author={Gary K. Iwamoto and Susan Konicek},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  volume={45 4},
BACKGROUND The immediate early genes (IE) of human cytomegalovirus (CMV) can be expressed in monocytic cells and are known to regulate viral and cellular genes. Interleukin-6 (IL-6) plays a central role in numerous inflammatory and immune processes. Interleukin-6 levels are increased in lung transplant patients clinically diagnosed with CMV pneumonitis. The regulation of IL-6 is dependent on various stimuli that include lipopolysaccharide (LPS), viruses, and other cytokines. These studies… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…