Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.

@article{Price2013CytomegalovirusCT,
  title={Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.},
  author={Richard Lee Price and Jieun Song and Katherine Bingmer and Tae Hyong Kim and Ji-Yeun Yi and Michal Oskar Nowicki and Xiaokui Mo and Todd C. Hollon and Eric Murnan and Christopher A. Alvarez-Breckenridge and Soledad D{\'i}az Fern{\'a}ndez and B. Devinder Kaur and Andreana L. Rivera and Michael J Oglesbee and Charles R Cook and E Antonio Chiocca and C K Kwon},
  journal={Cancer research},
  year={2013},
  volume={73 11},
  pages={3441-50}
}
To study the controversial role of cytomegalovirus (CMV) in glioblastoma, we assessed the effects of murine CMV (MCMV) perinatal infection in a GFAP-cre; Nf1(loxP/+); Trp53(-/+) genetic mouse model of glioma (Mut3 mice). Early on after infection, MCMV antigen was predominantly localized in CD45+ lymphocytes in the brain with active viral replication and local areas of inflammation, but, by 7 weeks, there was a generalized loss of MCMV in brain, confirmed by bioluminescent imaging. MCMV-infected… CONTINUE READING