Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination.

@article{Derhovanessian2013CytomegalovirusassociatedAO,
  title={Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination.},
  author={Evelyna Derhovanessian and Heidi Theeten and Karin Haehnel and Pierre van Damme and Nathalie Cools and Graham P Pawelec},
  journal={Vaccine},
  year={2013},
  volume={31 4},
  pages={685-90}
}
Influenza vaccination is less effective in the elderly compared to the young. Studies that have attempted to identify immune parameters correlating with satisfactory vaccine responses have yielded inconclusive results. Here, we correlate the distribution of different circulating CD4+ and CD8+ T-cell phenotypes with the humoral response to vaccination with Intanza, an intradermal seasonal vaccine, in 54 individuals of different ages. Subjects were stratified according to age (below or over 60… CONTINUE READING
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