Cytomegalovirus and the immune system in old age

  title={Cytomegalovirus and the immune system in old age},
  author={Dietmar Herndler-Brandstetter and Giovanni Almanzar and Beatrix Grubeck-Loebenstein},
Abstract A wide range of age-related alterations in immune system function have been reported and are referred to as immunosenescence. Much of the decline in immunoresponsiveness seen in elderly persons is due to changes within the T cell compartment because of the involution of the thymus. For this reason, infectious diseases are more frequent and severe in elderly persons, and the efficacy of vaccinations is low. Recently, scientific evidence has accumulated that chronic cytomegalovirus (CMV… CONTINUE READING