Cytomegalovirus UL97 mutations associated with ganciclovir resistance in immunocompromised patients from Argentina.

@article{Puch2004CytomegalovirusUM,
  title={Cytomegalovirus UL97 mutations associated with ganciclovir resistance in immunocompromised patients from Argentina.},
  author={Silvia I Sanchez Puch and Claudia Ochoa and Guadalupe Carballal and Carlos Zala and Pedro Cahn and Rosario Brunet and Horacio Salom{\'o}n and Cristina M. Videla},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2004},
  volume={30 3},
  pages={271-5}
}
BACKGROUND Prolonged therapy with ganciclovir (GCV) can result in the development of GCV-resistant strains due to mutations in the viral phosphotransferase (UL97 gene) and/or in the viral DNA polymerase (UL54 gene). OBJECTIVES The purpose of this study was to detect by molecular methods the most prevalent UL97 mutants which confer ganciclovir-resistance in immunocompromised populations. STUDY DESIGN Patients from two populations were selected: (a) renal transplant patients with active… CONTINUE READING