Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease

@inproceedings{Naeger2010CytomegalovirusSpecificTC,
  title={Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease},
  author={David M. Naeger and Jeffrey N Martin and Elizabeth Sinclair and Peter W. Hunt and David R. Bangsberg and Frederick M. Hecht and Priscilla Ying Hsue and Joseph M McCune and Steven G. Deeks},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND In healthy, HIV seronegative, CMV seropositive adults, a large proportion of T cells are CMV-specific. High-level CMV-specific T cell responses are associated with accelerated immunologic aging ("immunosenesence") in the elderly population. The impact of untreated and treated HIV infection on the frequency of these cells remains undefined. METHODOLOGY/PRINCIPAL FINDINGS We measured the proportion of CD4+ and CD8+ T cells responding to CMV pp65 and IE proteins was measured using… CONTINUE READING

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response among the elderly

  • RE Gress, SG Deeks
  • 2009

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