Cytolytic processes induced by TNF in L929 and K562 differ in DNA fragmentation mechanisms.

Abstract

OBJECTIVE Cytolytic activity of TNF was analysed at L929 and K562 tumor cell lines. METHODS TNF-mediated cytotoxicity was studied within 10(-6)-10(-17) M concentration range after 18 h of incubation with target cells. RESULTS TNF caused reliable cytotoxicity values in both cell lines, while L929 cells were more sensitive to cytolytic action of the… (More)

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