Cytolytic processes induced by TNF in L929 and K562 differ in DNA fragmentation mechanisms.


OBJECTIVE Cytolytic activity of TNF was analysed at L929 and K562 tumor cell lines. METHODS TNF-mediated cytotoxicity was studied within 10(-6)-10(-17) M concentration range after 18 h of incubation with target cells. RESULTS TNF caused reliable cytotoxicity values in both cell lines, while L929 cells were more sensitive to cytolytic action of the… (More)


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