Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndromes

@article{Kiladjian2006CytolyticFA,
  title={Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndromes},
  author={J-J Kiladjian and Emmanuelle Bourgeois and Ida Lobe and Thomas Braun and G{\'e}raldine Visentin and J Bourhis and Pierre Fenaux and Salem Chouaib and Anne Caignard},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={463-470}
}
Natural Killer (NK) cells are critical in host defense against malignant transformation and are potent antileukemic cytotoxic effectors. In the present study, we investigated the peripheral NK function in patients with myelodysplastic syndromes (MDS). We demonstrated that the peripheral NK cell population was quantitatively normal in MDS patients. Furthermore, NK cells displayed an expression of the activating natural cytotoxicity receptors (NCR) NKp46 and NKp30 as well as NKG2D similar to that… CONTINUE READING
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( B - CLL ) : a potential source for cellular immunotherapy

  • G Verhoef, PD Schouwer, J Ceuppens, JV Damme, W Goossens, M Boogaerts
  • 2003

Immunology of the myelodysplastic syndromes. In: Bennet JM (ed.) The Myelodysplastic Syndromes Syndromes: Pathobiology and Clinical Management

  • T. Hamblin
  • 2002

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