Cytolytic T lymphocytes with natural killer activity in thyroid infiltrate of patients with Hashimoto's thyroiditis: analysis at clonal level.

@article{Prete1986CytolyticTL,
  title={Cytolytic T lymphocytes with natural killer activity in thyroid infiltrate of patients with Hashimoto's thyroiditis: analysis at clonal level.},
  author={Gianfranco Del Prete and Enrico Maggi and Stefano Mariotti and A Tiri and Donata Vercelli and Paola Parronchi and Donatella Macchia and Aldo Pinchera and M. Rossino Ricci and Sergio Romagnani},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1986},
  volume={62 1},
  pages={52-7}
}
T Lymphocytes from thyroid infiltrates and peripheral blood (PB) of 3 patients with Hashimoto's thyroiditis (HT) were cloned using a microculture system previously shown to allow the clonal expansion of virtually all PB T lymphocytes from normal individuals. The phenotypic and functional features of a total number of 153 clones from thyroid infiltrates and 206 clones from PB were examined and compared with those of 272 clones derived from normal PB and spleens. The majority of clones derived… CONTINUE READING

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