Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.

@article{Knuth1989CytolyticTC,
  title={Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.},
  author={Alexander K. Knuth and Thomas Woelfel and E Klehmann and T. Boon and Karl H Meyer Zum B{\"u}schenfelde},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 8},
  pages={2804-8}
}
Cytolytic T-lymphocyte (CTL) clones against an autologous melanoma (SK-MEL-29) were generated by mixed lymphocyte tumor culture and subsequent cloning of responder lymphocytes at limiting dilutions. These CTL clones lysed autologous melanoma but not autologous Epstein-Barr virus-transformed B cells and none of the allogeneic tumor targets included in the specificity analysis. The lysis of autologous melanoma targets could be inhibited by monoclonal antibodies against monomorphic HLA class I… CONTINUE READING

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