Corpus ID: 38545642

Cytolytic Activity and Molecular Feature of Cardiotoxin and Cardiotoxin-like Basic Protein: The Electrostatic Potential Field Is an Important Factor for Cell Lytic Activity.

@article{Kawaguchi2015CytolyticAA,
  title={Cytolytic Activity and Molecular Feature of Cardiotoxin and Cardiotoxin-like Basic Protein: The Electrostatic Potential Field Is an Important Factor for Cell Lytic Activity.},
  author={Yuki Kawaguchi and Yohei Tatematsu and A. Tabata and H. Nagamune and K. Ohkura},
  journal={Anticancer research},
  year={2015},
  volume={35 8},
  pages={
          4515-9
        }
}
BACKGROUND/AIM Cardiotoxin (CT) is a well-known cell lytic protein and has been purified from cobra venom. Cardiotoxin-like basic protein (CLBP) has two amino acid insertions and does not exhibit cell lytic activity. The molecular features of these CT family proteins were examined in the present study using molecular modeling and molecular simulation techniques. MATERIALS AND METHODS Molecular models of CT and CLBP were constructed based on the X-ray data of Naja mossambica mossambica CT VII4… Expand
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