Cytology‐based screening for anal intraepithelial neoplasia in women with a history of cervical intraepithelial neoplasia or cancer

  title={Cytology‐based screening for anal intraepithelial neoplasia in women with a history of cervical intraepithelial neoplasia or cancer},
  author={Christoph Wohlmuth and Zeina Ghorab and Michael Shier and Jill Tinmouth and Irving E. Salit and Allan Covens and Liying Zhang and Danielle Vicus},
  journal={Cancer Cytopathology},
  pages={140 - 147}
High‐risk human papillomavirus (HPV) has been identified in the pathogenesis of anal cancer. The purpose of this study was to assess the prevalence of abnormal anal cytology and HPV in women aged ≥40 years who have a history of high‐grade cervical squamous intraepithelial lesion (SIL) or cancer and to estimate the prevalence of anal intraepithelial neoplasia (AIN) using cytology as the primary screening modality. 
Liquid‐based cytology and HPV DNA test in anal specimens from women with cervical cancer
This work aimed to identify high‐risk HPV and cytological atypia in anal samples from women diagnosed with invasive squamous cell carcinoma of the cervix.


Anal carcinoma in human immunodeficiency virus‐positive men: results of a prospective study from Germany
Background  Anal intraepithelial neoplasia (AIN), a human papillomavirus (HPV)‐associated potential precursor lesion of anal cancer, is frequent among human immunodeficiency virus (HIV)‐positive men
Anal Intraepithelial Neoplasia in Women With Genital Intraepithelial Neoplasia
Patients with cervical, vulvar, and vaginal intraepithelial neoplasia should be screened with high-resolution anoscopy in order to assess the prevalence of anal intraepidemic neoplAS, and McNemar's test compared the two screening methods.
The role of cytology (Pap tests) and human papillomavirus testing in anal cancer screening
Anal cytology and HPV detection have high sensitivity but low specificity for detecting AIN 2+.
Screening for Anal Cancer in Women
While there are no data yet to demonstrate that identification and treatment of anal HSIL leads to reduced risk of anal cancer, women in groups at the highest risk should be queried for anal cancer symptoms and required to have digital anorectal examinations to detect anal cancers.
Anal cytology as a screening tool for anal squamous intraepithelial lesions.
Anal cytology may be a useful screening tool to detect ASIL, particularly in HIV-positive men, and anal cytology should be used in conjunction with histopathologic confirmation.
Risk of Anal Cancer in a Cohort With Human Papillomavirus–Related Gynecologic Neoplasm
Women with human papillomavirus–related gynecologic neoplasm are at higher risk for developing anal cancer compared with the general population, and this high-risk population may benefit from close observation and screening for anal cancer.
Practising high-resolution anoscopy.
The technique of HRA, its uses and challenges in prevention of anal cancer are described, which poses several additional challenges compared with cervical colposcopy.
The value of anal cytology and human papillomavirus typing in the detection of anal intraepithelial neoplasia: a review of cases from an anoscopy clinic
Anal cytology by the Palefsky method is simple to undertake, has a sensitivity and specificity comparable with cervical cytology, and can therefore be used as the basis of a pilot screening project in centres with large cohorts of HIV positive homosexual men who have a high risk of developing anal carcinoma.