Cytological and molecular characterization of secretory breast carcinoma

  title={Cytological and molecular characterization of secretory breast carcinoma},
  author={Irene Carretero-Barrio and Almudena Sant{\'o}n and Tamara Caniego Casas and Elena L{\'o}pez Miranda and Mar{\'i}a Eugenia Reguero-Callejas and Bel{\'e}n P{\'e}rez-Mies and Amparo Benito and Jos{\'e} Palacios},
  journal={Diagnostic Cytopathology},
  pages={E174 - E180}
Secretory breast carcinoma is a rare neoplasm, histologically well‐characterized, and secondary to ETV6‐NTRK3 gene fusion, whose cytological features are scarcely described in the literature. We report the case of a woman with a history of secretory breast carcinoma 8 years before, who presented a periareolar nodule. A recurrence was diagnosed by fine‐needle aspiration based on the cytomorphological features and pan‐TRK immunocytochemistry on the cell block, and the patient underwent a… 

Advancement of secretory breast carcinoma: a narrative review

SBC lacks specific clinical manifestations and has typical pathological and molecular characteristics, including intracellular and extracellular eosinophilic secretions, immune spectrum similar to hormone receptor-positive tumors, and the ETV6-NTRK3 fusion gene.



Cytodiagnosis of secretory carcinoma of the breast: A report on two cases

Two cases of secretory carcinoma of the breast presenting as a breast mass, one in a 24‐year‐old female and the other in a 40‐year-old female are reported, highlighting their appearance at FNAC.


The cytological findings of secretory carcinoma are presented in a 57-year-old woman with a two-year history of right breast mass and hypercellularity and absence of bipolar naked nuclei are important clues in the initial diagnosis of malignancy.

Fine needle aspiration cytodiagnosis of secretory carcinoma of the breast

The cytodiagnostic criteria for SC of the breast, characteristic cytological features which are useful in a correct FNAC diagnosis and differentiation from other pertinent breast carcinomas, are discussed.

Needle aspiration cytology, immunocytochemistry, and electron microscopy in a rare case of secretory carcinoma of the breast in an elderly woman

Needle aspiration was performed on a breast mass in a 91‐year‐old woman and showed a positivity for mucin by alcian blue stain in the vacuolated cells which was periodic acid‐Schiff positive and resistant to diastase digestion.

Secretory carcinoma of the breast associated with juvenile papillomatosis in a 12-year-old girl. A case report.

A rare case of juvenile secretory carcinoma (SC) associated with juvenile papillomatosis (JP) is described and the relationship between SC and JP is discussed.

Secretory breast carcinoma in a man diagnosed by fine needle aspiration biopsy. A case report.

The cytomorphologic features of secretory breast carcinoma seem to be alike in men and women and are sufficiently characteristic to permit a definitive preoperative diagnosis from fine needle aspiration biopsy smears.

Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature

It is revealed that secretory breast carcinoma is a distinct subset of invasive breast carcinomas, with expression of basal-like markers, with prognostic significance of the basal- like markers expression in secretory breasts.

Utility of an immunocytochemical analysis for pan‐Trk in the cytodiagnosis of secretory carcinoma of the salivary gland

Although all cases of SC do not always show positive immunoreactivity for pan‐Trk, immunocytochemical analysis for pan-Trk may be useful for the cytodiagnosis of SC along with assessment of the characteristic cytological features.

Clinicopathologic and molecular characteristics of 44 patients with pure secretory breast carcinoma

Although axillary lymph node metastasis, local recurrence, or distant metastasis may occur, SBC is also considered an indolent neoplasm with a good prognosis.

Pan-TRK Immunohistochemistry

Secretory carcinoma is a special-type breast carcinoma underpinned by a recurrent t(12;15)(p13;q25) translocation resulting in ETV6-NTRK3 gene fusion. Immunohistochemistry (IHC) using a pan-TRK