Cytological and biochemical evidence for a gonad-preferential interplay of SmFKBP12 and SmTbetaR-I in Schistosoma mansoni.

@article{Knobloch2004CytologicalAB,
  title={Cytological and biochemical evidence for a gonad-preferential interplay of SmFKBP12 and SmTbetaR-I in Schistosoma mansoni.},
  author={Juergen Knobloch and Alessandro Rossi and Ahmed O. Osman and Philip T. Loverde and M Klinkert and Christoph G Grevelding},
  journal={Molecular and biochemical parasitology},
  year={2004},
  volume={138 2},
  pages={227-36}
}
In eukaryotes, FK506-binding proteins with a molecular weight of 12 kDa (FKBP12s) influence a variety of signal transduction pathways that regulate cell division, differentiation, and ion homeostasis. Amongst these, TGFbeta signaling and calcineurin (CN) phosphatase activity is modulated by FKBP12 via binding to TGFbeta-family type I receptors (TbetaR-Is) or to the CN subunit A, respectively. In this work, we demonstrate the tissue-specific expression of the Schistosoma mansoni FKBP12 homologue… CONTINUE READING