Cytolethal distending toxin generates cell death by inducing a bottleneck in the cell cycle.

@article{Ceelen2006CytolethalDT,
  title={Cytolethal distending toxin generates cell death by inducing a bottleneck in the cell cycle.},
  author={Liesbeth M. Ceelen and Annemie Decostere and Richard Ducatelle and Freddy Haesebrouck},
  journal={Microbiological research},
  year={2006},
  volume={161 2},
  pages={109-20}
}
Cytolethal distending toxin (CDT) is a bacterial protein that is widely distributed among gram-negative bacteria including Escherichia coli, Campylobacter spp., enterohepatic Helicobacter spp., Actinobacillus actinomycetemcomitans and Haemophilus ducreyi. In vitro studies demonstrated that it is able to stop proliferation of various cell lines. The toxin is composed of three subunits designated CDTs A, B and C. The B subunit targets the eukaryotic DNA and triggers a signalling pathway involving… CONTINUE READING
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