Cytolethal distending toxin damages the oral epithelium of gingival explants.

@article{DamekPoprawa2011CytolethalDT,
  title={Cytolethal distending toxin damages the oral epithelium of gingival explants.},
  author={Monika Damek-Poprawa and Mir Haris and Alla V Volgina and Jonathan M Korostoff and J M Dirienzo},
  journal={Journal of dental research},
  year={2011},
  volume={90 7},
  pages={874-9}
}
UNLABELLED The cytolethal distending toxin (Cdt), expressed by the periodontal pathogen Aggregatibacter actinomycetemcomitans, inhibits the proliferation of cultured epithelial cells by arresting the cell cycle. The gingival epithelium is an early line of defense against microbial assault. When damaged, bacteria collectively gain entry into underlying connective tissue where microbial products can affect infiltrating inflammatory cells, leading to the destruction of the attachment apparatus… CONTINUE READING