Cytolethal Distending Toxin in Isolates of Aggregatibacter actinomycetemcomitans from Ghanaian Adolescents and Association with Serotype and Disease Progression

@inproceedings{berg2013CytolethalDT,
  title={Cytolethal Distending Toxin in Isolates of Aggregatibacter actinomycetemcomitans from Ghanaian Adolescents and Association with Serotype and Disease Progression},
  author={C H{\"o}glund {\AA}berg and Georgios N Antonoglou and Dorte Haubek and Francis Kwamin and Rolf L K Claesson and Anders Johansson},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND AND OBJECTIVES The cytolethal distending toxin (Cdt) is a highly conserved exotoxin that are produced by a number of Gram negative bacteria, including Aggregatibacter actinomycetemcomitans, and affects mammalian cells by inhibiting cell division and causing apoptosis. A complete cdt-operon is present in the majority of A. actinomycetemcomitans, but the proportion of isolates that lack cdt-encoding genes (A, B and C) varies according to the population studied. The objectives of this… CONTINUE READING
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