Cytokinesis and cancer: Polo loves ROCK'n' Rho(A).

  title={Cytokinesis and cancer: Polo loves ROCK'n' Rho(A).},
  author={Jing zhou Li and Jue Wang and Hong Jiao and Ji Liao and Xingzhi Xu},
  journal={Journal of genetics and genomics = Yi chuan xue bao},
  volume={37 3},
Cytokinesis is the last step of the M (mitosis) phase, yet it is crucial for the faithful division of one cell into two. Cytokinesis failure is often associated with cancer. Cytokinesis can be morphologically divided into four steps: cleavage furrow initiation, cleavage furrow ingression, midbody formation and abscission. Molecular studies have revealed that RhoA as well as its regulators and effectors are important players to ensure a successful cytokinesis. At the same time, Polo-like kinase… CONTINUE READING