Cytokinesis: IQGAPs find a function

  title={Cytokinesis: IQGAPs find a function},
  author={Laura M Machesky},
  journal={Current Biology},
Mammalian proteins known as ‘IQGAPs’ are a classic product of modern molecular biology. They were originally identified as putative Ras GTPase-activating proteins (GAPs), on the basis of amino-acid sequence similarity [1,2], but do not appear to bind to Ras or have GAP activity [3–5]. The function of IQGAPs in mammalian cells is still unknown, but two groups have shown recently that the Saccharomyces cerevisiae homolog of mammalian IQGAPs, Iqg1p/Cyk1p, is a component of the actin ring which… CONTINUE READING

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