Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.

@article{Barthson2011CytokinesTN,
  title={Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.},
  author={Jenny Barthson and Carla M. Germano and Fabrice Moore and Adriano Maida and Daniel J Drucker and Piero Marchetti and Conny A. Gysemans and Chantal Mathieu and Gabriel N{\'u}{\~n}ez and Andrea Jurisicova and Decio L. Eizirik and Esteban N Gurzov},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 45},
  pages={
          39632-43
        }
}
Type 1 diabetes is characterized by local inflammation (insulitis) in the pancreatic islets causing β-cell loss. The mitochondrial pathway of apoptosis is regulated by the balance and interaction between Bcl-2 members. Here we clarify the molecular mechanism of β-cell death triggered by the pro-inflammatory cytokines tumor necrosis factor (TNF)-α and interferon (IFN)-γ. The combination of TNF-α + IFN-γ induced DP5, p53 up-regulated modulator of apoptosis (PUMA), and Bim expression in human… CONTINUE READING
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Bim Modulates Apoptosis in Pancreatic -Cells 39642 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

S. A. Lipton, E. Lugli, +36 authors G. Kroemer
NOVEMBER 11, • 2011
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