Cytokines that regulate autoimmunity.

@article{Diveu2008CytokinesTR,
  title={Cytokines that regulate autoimmunity.},
  author={Caroline Diveu and Mandy J McGeachy and Daniel J. Cua},
  journal={Current opinion in immunology},
  year={2008},
  volume={20 6},
  pages={
          663-8
        }
}
Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGFbeta acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of RORgamma-dependent Th17 cells. IL-23--a member of the IL-12 family--activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when dysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27--another IL-12 family member--plays… CONTINUE READING

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