Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.

@article{Eizirik1994CytokinesSH,
  title={Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.},
  author={Decio L. Eizirik and Stellan Sandler and Nils Welsh and M. {\'C}etkovi{\'c}-Cvrlje and A Nieman and David A. Geller and Daniel G. Pipeleers and Klaus Bendtzen and Claes Hellerstr{\"o}m},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 5},
  pages={1968-74}
}
Cytokines have been proposed as inducers of beta-cell damage in human insulin-dependent diabetes mellitus via the generation of nitric oxide (NO). This concept is mostly based on data obtained in rodent pancreatic islets using heterologous cytokine preparations. The present study examined whether exposure of human pancreatic islets to different cytokines induces NO and impairs beta-cell function. Islets from 30 human pancreata were exposed for 6-144 h to the following human recombinant… CONTINUE READING
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