Cytokines suppress apoptosis independent of increases in reactive oxygen levels.

@article{Packham1996CytokinesSA,
  title={Cytokines suppress apoptosis independent of increases in reactive oxygen levels.},
  author={Graham Packham and Richard A. Ashmun and John L. Cleveland},
  journal={Journal of immunology},
  year={1996},
  volume={156 8},
  pages={2792-800}
}
Antioxidants suppress apoptosis induced by diverse stimuli in many cells, including immune cells, suggesting that reactive oxygen species (ROS) are common mediators of apoptosis. We evaluated the potential role for ROS in the apoptosis of myeloid progenitors following withdrawal of survival factors and in the apoptosis triggered by enforced c-myc expression, two model systems of programmed cell death. ROS are potential mediators of these cell deaths, as low concentrations of H2O2 (0.1-0.2 mM… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…