Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity.

@article{Owen1997CytokinesRM,
  title={Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity.},
  author={Caroline A Owen and Melody A. Campbell and S S Boukedes and Edward J. Campbell},
  journal={The American journal of physiology},
  year={1997},
  volume={272 3 Pt 1},
  pages={
          L385-93
        }
}
Membrane-bound leukocyte elastase activity on neutrophils may have potent proinflammatory effects. Herein, we report the effects of tumor necrosis factor-alpha (TNF-alpha), platelet-activating factor (PAF), N-formyl-leucyl-methionyl-phenylalanine (fMLP), and interleukin-8 (IL-8) on membrane-bound elastase expression. TNF-alpha or PAF alone induced only approximately two- to threefold increases in membrane-bound elastase but exhibited marked dose- and time-dependent priming effects for… CONTINUE READING
Highly Cited
This paper has 45 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations