Cytokines regulate matrix metalloproteinases and migration in cardiac fibroblasts.

@article{Brown2007CytokinesRM,
  title={Cytokines regulate matrix metalloproteinases and migration in cardiac fibroblasts.},
  author={Russell Brown and Gayle M Jones and Rebecca E Laird and Paul S. Hudson and Carlin S. Long},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={362 1},
  pages={
          200-5
        }
}
We sought to define the relationship between cytokine stimulated release of matrix metalloproteinases (MMPs) and cell migration using adult rat cardiac fibroblasts. Interleukin-1beta (IL-1beta) increased release of MMP-2, -3, and -9, and TIMP-1, by 3-6-fold, measured by immunoblotting and gel zymography. Tumor necrosis factor-alpha (TNFalpha) augmented IL-1beta stimulated release of MMP-9, but not MMP-2 or -3. Transforming growth factor-beta1 (TGFbeta1) attenuated all the responses to IL-1beta… CONTINUE READING

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