Cytokines profile in hypertensive patients with left ventricular remodeling and dysfunction.

Abstract

There is strong evidence that inflammatory mediators play a key role in the progression to heart failure in patients with systemic hypertension (HTN). The present study aimed to identify a set of cytokines that are associated with early left ventricular (LV) remodeling and dysfunction as captured by echocardiography in patients with HTN in a cross-sectional case-control study nested within the FLEMish study on ENvironment, Genes and Health Outcome. We identified three groups of participants from the cohort: normotensive subjects (normotension; n = 30), HTN with normal LV structure and function (HTN [LV-]; n = 30), and HTN with evidence of adverse LV remodeling (HTN [LV+]; n = 50). We measured cytokines using a 63-plex Luminex platform. Using partial least squares-discriminant analysis, we constructed three latent variables from the measured cytokines that explained 35%-45% of the variance between groups. We identified five common cytokines (interleukin 18, monokine induced by gamma interferon, hepatocyte growth factor, epithelial neutrophil-activating peptide 78, and vascular endothelial growth factor D) with a stable signal which had a major impact on the construction of the latent variables. Among these cytokines, after adjustment for confounders, interleukin 18 remained significantly different between HTN participants with and without LV involvement (P = .02). Moreover, granulocyte-macrophage colony-stimulating factor and leptin showed a consistent upward trend in all HTN patients compared with normotensive subjects. In conclusion, in HTN patients with LV remodeling or/and dysfunction, we identified a set of cytokines strongly associated with LV maladaptation. We also found a distinct profile of inflammatory biomarkers that characterize HTN.

DOI: 10.1016/j.jash.2015.10.003

Cite this paper

@article{Kuznetsova2015CytokinesPI, title={Cytokines profile in hypertensive patients with left ventricular remodeling and dysfunction.}, author={Tatiana Kuznetsova and François Haddad and Judita Knez and Yael Rosenberg-Hasson and Janine Sung and Nicholas Cauwenberghs and Lutgarde Thijs and Ioannis Karakikes and Holden Maecker and Kenneth W . Mahaffey and Joseph C Wu and Jan A Staessen}, journal={Journal of the American Society of Hypertension : JASH}, year={2015}, volume={9 12}, pages={975-84.e3} }