Cytokines of the γc family control CD4+ T cell differentiation and function

  title={Cytokines of the γc family control CD4+ T cell differentiation and function},
  author={Hidehiro Yamane and W. Jack Christie Edwin J. Crossman Peter J. Doherty A Paul},
  journal={Nature Immunology},
Naive CD4+ T cells undergo massive proliferation and differentiation into at least four distinct helper T cell subsets after recognition of foreign antigen–derived peptides presented by dendritic cells. Each helper T cell subset expresses a distinct set of genes that encode unique transcription factor(s), as well as hallmark cytokines. The cytokine environment created by activated CD4+ T cells, dendritic cells and/or other cell types during the course of differentiation is a major determinant… CONTINUE READING
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